Valdecoxib: the rise and fall of a COX-2 inhibitor
نویسندگان
چکیده
منابع مشابه
Valdecoxib : the rise and fall of a COX-2 inhibitor.
INTRODUCTION Valdecoxib is a cyclooxygenase-2 (COX-2) selective anti-inflammatory drug. It is associated with a reduced incidence of gastrointestinal complications and is potentially useful for patients with rheumatological diseases requiring longer term anti-inflammatory treatment. AREAS COVERED Due to a perceived increased risk of thrombotic events, particularly cardiovascular hazards and r...
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The pharmacokinetics and metabolism of valdecoxib, a potent cyclooxygenase-2 selective inhibitor, were investigated in mice. Valdecoxib was extensively metabolized after a single 5 mg/kg oral administration of [(14)C]valdecoxib and elimination of unchanged drug was minor (less than 1%) in male and female mice. The total mean percentage of administered radioactive dose recovered was 99.8% in the...
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چکیده ندارد.
Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human.
Valdecoxib is a potent and specific inhibitor of cyclooxygenase-2, which is used for the treatment of rheumatoid arthritis, osteoarthritis, and the dysmenorrhea pain. Eight male human subjects each received a single 50-mg oral dose of [(14)C]valdecoxib. Urine, feces, and blood samples were collected after administration of the radioactive dose. Most of the radioactivity in plasma was associated...
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ژورنال
عنوان ژورنال: Expert Opinion on Pharmacotherapy
سال: 2013
ISSN: 1465-6566,1744-7666
DOI: 10.1517/14656566.2013.783568